Nucleophilic trifluoromethylation tamed

The paper reviews our recent findings on the trifluoromethylation of organic compounds using TMSCF3. Direct preparation of trifluoromethylated ketones from esters, amides from alcohols and an-lines from imines is described. Trifluoromethylated amino alcohols are also prepared using a three-component condensation chemistry. (C) 2001 Elsevier Science B.V. All rights reserved.