期刊
JOURNAL OF APPLIED PHYSIOLOGY
卷 91, 期 6, 页码 2451-2458出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jappl.2001.91.6.2451
关键词
augmented breath; vagal afferents
资金
- NINDS NIH HHS [P01-NS-35702] Funding Source: Medline
The mechanisms by which chronic cervical spinal cord injury alters respiratory function and plasticity are not well understood. We speculated that spinal hemisection at C-2 would alter the respiratory pattern controlled by vagal mechanisms. Expired volume (VE) and respiratory rate (RR) were measured in anesthetized control and C-2-hemisected rats at 1 and 2 mo postinjury. C-2 hemisection altered the pattern of breathing at both postinjury time intervals. Injured rats utilized a higher RR and lower VE to maintain the same minute ventilation as control rats. After bilateral vagotomy, the pattern of breathing in injured rats was not different from controls. The frequency of augmented breaths was higher in injured rats at 2 mo postinjury before vagotomy; however, the VE of augmented breaths was not different between groups, In conclusion, C-2 hemisection alters the pattern of breathing at 1 and 2 mo postinjury via vagal mechanisms.
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