期刊
MECHANISMS OF DEVELOPMENT
卷 109, 期 2, 页码 395-397出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0925-4773(01)00533-0
关键词
Wnts; frizzled; secreted Frizzled-related protein; neocortex; ganglionic eminence; SAGE
Writs are a family of secreted proteins involved in multiple developmental mechanisms during nervous system development, including cell proliferation, cell migration, axon guidance and specification of cell positional information. We report here the expression of sFRP-1 mRNA, encoding a putative inhibitor of Wnt, in the developing mouse neocortex during the entire period when neurons for the neocortex are born. We show that sFRP-1 mRNA expression is spatially restricted to the proliferative zones during the period, when neurons are known to be generated in large numbers for the enlarging cortical plate. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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