期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 115, 期 4, 页码 1004-1006出版社
BLACKWELL PUBLISHING LTD
DOI: 10.1046/j.1365-2141.2001.03184.x
关键词
thrombopoietin; thrombocytopenia; immune; purpura; platelet kinetics
类别
Pre- and post-treatment serum thrombopoietin (TPO) concentration was measured In 35 patients with immune thrombocytopenic purpura (ITP). Mean post-treatment levels were significantly lower (P = 0.02) than pretreatment and not different for treatment modality. No significant correlation between pre- or post-treatment TPO and platelet counts was demonstrable (R = -0.325, P = 0.056 and R = -0.227, P = 0.190 respectively). In patients with very low platelet counts (less than or equal to20 x 10(9)/l), pretreatment serum TPO was significantly higher than in patients with higher counts (P = 0.033). The logarithm of the platelet turnover rate. measured in 15 patients, correlated with pretreatment TPO levels (R = 0.64). These findings suggest a contributory role for TPO in the mechanism of ITP.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据