The human dopamine transporter gene: gene organization, transcriptional regulation, and potential involvement in neuropsychiatric disorders

The dopamine transporter is a plasma membrane protein that controls the spatial and temporal domains of dopamine neurotransmission through the accumulation of extracellular dopamine. The dopamine transporter may play a role in numerous dopamine-linked neuropsychiatric disorders. We review the cloning and organization of the human dopamine transporter gene, polymorphisms in its coding and noncoding sequence, and emerging data on its transcriptional regulation. (C) 2001 Elsevier Science B.V. All rights reserved.