期刊
IMMUNITY
卷 15, 期 6, 页码 1011-1026出版社
CELL PRESS
DOI: 10.1016/S1074-7613(01)00253-9
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资金
- NIAID NIH HHS [R01 AI060921] Funding Source: Medline
The hematopoietic cell-specific adaptor protein, SLP-76, is critical for T cell development and mature T cell receptor (TCR) signaling; however, the structural requirements of SLP-76 for mediating thymopoiesis and mature T cell function remain largely unknown. In this study, transgenic mice were generated to examine the requirements for specific domains of SLP-76 in thymocytes and peripheral T cells in vivo. Examination of mice expressing various mutants of SLP-76 on the null background demonstrates a differential requirement for specific domains of SLP-76 in thymocytes and T cells and provides new insight into the molecular mechanisms underlying SLP-76 function.
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