期刊
INSECT MOLECULAR BIOLOGY
卷 10, 期 6, 页码 561-571出版社
BLACKWELL SCIENCE LTD
DOI: 10.1046/j.0962-1075.2001.00296.x
关键词
defensin; midgut; immunity; genes; blood-sucking
The Stomoxys midgut defensin (Smd) family of genes are exclusively expressed In the anterior midgut of adult flies. Their putative function is protection of the stored bloodmeal from microbial attack. Smd genes are constitutively expressed, up-regulated in response to a bloodmeal and further up-regulated by immune stimulation per os but only in the presence of a bloodmeal not a sugar meal. Smd genes are down-regulated in response to a systemic immune challenge. Smd gene constructs transfected Into I(2)mbn cells undertake constitutive expression but are not up-regulated by immune challenge. Electrophoretic mobility shift assays (EMSA) suggest the rel-like sites In the proximal promoter region of Smd genes do not bind midgut factors and so are non-functional.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据