期刊
TRENDS IN NEUROSCIENCES
卷 24, 期 12, 页码 713-719出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0166-2236(00)01996-2
关键词
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资金
- NIMH NIH HHS [MH 57535, MH 57760] Funding Source: Medline
Recent pharmacological and genetic studies have dramatically expanded the list of neurotransmitters, hormones, cytokines, enzymes, growth factors, and signaling molecules that influence aggression. In spite of this expansion, serotonin (5-HT) remains the primary molecular determinant of inter-male aggression, whereas other molecules appear to act indirectly through 5-HT signaling. We review evidence of interactions among these molecules and aggressive behavior. Slight modulations in 5-HT levels, turnover, and metabolism, or in receptor subtype activation, density, and binding affinity affect aggression. Activation of specific 5-HT receptors evokes distinct, but highly interacting, second messenger systems and multiple effectors. Understanding the interactions between 5-HT receptor subtypes should lead to novel insights into the molecular mechanisms of aggression.
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