期刊
BEHAVIOURAL PHARMACOLOGY
卷 12, 期 8, 页码 641-645出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00008877-200112000-00009
关键词
SR141716; CB1 receptor; food maintained responding; CRF; rat
Cannabinoids increase food intake, via CB1 receptors. The CB1 antagonist, SR141716, has been reported to decrease palatable food consumption in both operant and non-operant procedures. Similarly, CB1 receptor blockade diminished responding for normal food pellets under a fixed-ratio 15 (FR-15) schedule of reinforcement. The present experiment investigated whether the control of a continuous schedule of reinforcement (CRF) for sucrose pellets would be sensitive to the CB1 antagonist in mildly deprived rats. SR141716 dose-dependently reduced responding in a CRF procedure, by increasing post-reinforcement pauses. Together with formerly published conclusions, the data suggest that CB1 blockade reduces the rewarding efficacy of both palatable and non-palatable food. (C) 2001 Lippincott Williams & Wilkins.
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