期刊
MOLECULAR ECOLOGY
卷 10, 期 12, 页码 2765-2773出版社
BLACKWELL PUBLISHING LTD
DOI: 10.1046/j.1365-294X.2001.t01-1-01402.x
关键词
class II; divergent allele advantage; MHC; Pema EB; Peromyscus; symmetric balancing selection
We studied population polymorphism at a major histocompatibility complex (MHC) class II beta gene in the deer mouse (Peromyscus maniculatus). We found that: (i) a single population of P. maniculatus has significantly higher levels of DNA and protein sequence diversity than worldwide samples from homologous genes in other taxa, including humans and mice; and (ii) the genealogy of allelic sequences in P. maniculatus deviates significantly from theoretical expectation under a model of symmetric balancing selection, in that alleles are relatively more divergent than expected. We suggest that the observation of high levels of pairwise allelic sequence divergence and deviation of the genealogy from theoretical expectation in P. maniculatus together provide support for a divergent allele advantage model for the maintenance of MHC polymorphism.
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