期刊
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
卷 132, 期 6, 页码 1173-1176出版社
CONSULTANTS BUREAU
DOI: 10.1023/A:1014559331402
关键词
mitochondria; beta-amyloid; neurodegeneration; cyclosporine-sensitive mitochondrial channels; lipid peroxidation
beta-Amyloid peptide fragment 25-35 potentiated phosphate- and calcium-induced opening of mitochondrial channels and caused swelling of mitochondria (even without exogenous calcium and phosphate). These changes were accompanied by accumulation of lipid peroxidation products in mitochondria. Specific inhibitors of mitochondrial channels ADP and cyclosporine A prevented beta-amyloid peptide-induced swelling of mitochondria. Our findings suggest that potentiation of mitochondrial channel opening is an important component of the neurodegenerative effect of beta-amyloid.
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