期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 56, 期 12, 页码 B520-B523出版社
GERONTOLOGICAL SOCIETY AMER
DOI: 10.1093/gerona/56.12.B520
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资金
- NIA NIH HHS [AG-16794] Funding Source: Medline
- NIEHS NIH HHS [ES 7992] Funding Source: Medline
Senescence is a complex and multifactorial process that may predispose organisms to altered responses to environmental stressors. The cytokine interleukin-6 (IL-6) is expressed by a variety of cells and is one of the earliest mediators of the acute inflammatory response. In this study, the level of IL-6 mRNA in younger (7 months) and old (23 months) mice was determined in the tissue of several organs with or without stimulation with lipopolysaccharide (LPS). Whereas younger animals had a basal expression of IL-6 mRNA in all organs, this was undetectable in the old animals. In contrast, when the mice were injected with LPS, in a majority of the organ tissues there was a robust stimulation of IL-6 mRNA in the old mice whereas the younger animals had a more variable response. These data indicate that the aging process may predispose animals to an exaggerated and potentially harmful inflammatory response.
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