Four new bioactive pyrrole-derived alkaloids from the marine sponge Axinella brevistyla

Four new alkaloids (1-4) were isolated from the marine sponge Axinella brevistyla, and their structures were determined on the basis of spectroscopic analysis. The alkaloids 1-4 were antifungal against the yeast Saccharomyces cerevisiae at <1.0, <1.0, 30, and 100 mug/disk, respectively. Compounds 1-3 also exhibited cytotoxicity against L1210 cells with IC50 values of 1.1, 0.66, and 2,5 mug/mL, respectively.