期刊
JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS
卷 6, 期 3, 页码 225-230出版社
NATURE PUBLISHING GROUP
DOI: 10.1046/j.0022-202x.2001.00045.x
关键词
alpha-toxin; keratinocytes; platelet-activating factor; protein A; Staphylococcus aureus; superantigens
类别
资金
- NCRR NIH HHS [5M01 RR0051] Funding Source: Medline
- NHLBI NIH HHS [HL37260, HL62996] Funding Source: Medline
- NIAMS NIH HHS [AR41256] Funding Source: Medline
- PHS HHS [K081993] Funding Source: Medline
Skin infections with Staphylococcus aureus are not only an important cause of morbidity and even mortality, but are thought to serve as initiation and/or persistance factors for numerous inflammatory skin diseases, including psoriasis and atopic dermatitis. One mechanism by which S. aurens can modulate the immune system is through the production of proteins such as superantigenic toxins, Protein A, as well through the cytolytic alpha-toxin. This review serves to discuss the biology of these three types of proteins, with emphasis on their ability to stimulate the production of powerful pro-inflammatory lipid- and protein-derived cytokines in keratinocytes. Characterization of interactions between these proteins and the keratinocyte can provide a better understanding of how bacterial infection modulates inflammatory skin diseases, as well as provide the basis for improved therapies involving antibacterial agents.
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