期刊
JOURNAL OF APPLIED CRYSTALLOGRAPHY
卷 34, 期 -, 页码 773-776出版社
INT UNION CRYSTALLOGRAPHY
DOI: 10.1107/S0021889801012869
关键词
-
Three-dimensional bead models of proteins in solution are routinely determined from one-dimensional small-angle X-ray scattering (SAXS) data. The Situs software provides a novel set of visualization and registration procedures to facilitate the localization of protein structures in low-resolution SAXS bead models. The docking algorithm takes advantage of a reduced representation of the input data sets by means of topology-representing neural networks to expedite the rigid-body search. The precision of the docking was tested on ten different simulated bead models: for >100 beads typically arising in SAXS models, a docking precision of the order of an (a) over circle ngstr(o)double over dotm can be achieved. The shape-matching score captured the correct solutions in all ten trial cases and was sufficiently stringent to yield unique matches in seven systems. A size-invariant shape descriptor of 'sphericity' is proposed to assess the onset of ambiguity in the matching of globular molecules. The software, a tutorial and supplementary data are available at http://situs.scripps.edu/saxs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据