期刊
AUTOIMMUNITY REVIEWS
卷 12, 期 10, 页码 947-953出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.autrev.2013.02.006
关键词
Blood-brain barrier; Corticotropin-releasing hormone; Flavonoids; Neurotensin; Neuropeptides; Inflammation; Microglia; Mast cells; Multiple sclerosis; Stress
类别
Substantial evidence indicates that stress can precipitate or worsen symptoms of inflammation in general and more specifically in multiple sclerosis (MS), a demyelinating, autoimmune disease characterized by inflammation of the central nervous system (CNS). However, the mechanism of how stress affects MS is not well understood. We reviewed publications in PubMed since 1995 and propose that neuropeptides secreted under stress, such as corticotropin releasing hormone (CRH) and neurotensin (NT), activate microglia and mast cells to release inflammatory molecules. These lead to maturation and activation of T17 autoimmune cells, disruption of the blood-brain barrier (BBB) and T cell entry into the CNS, thus promoting brain inflammation and contributing to MS pathology. Reduction of stress and inhibition of these processes by select flavonoids could provide novel therapeutic approaches. (c) 2013 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据