期刊
AUTOIMMUNITY REVIEWS
卷 12, 期 12, 页码 1123-1128出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.autrev.2013.06.015
关键词
Autoantibody; Tumor-associated antigen; Immunoproteomics; Immunodiagnosis; Cancer
类别
资金
- NIH [5SC1CA166016, 5G12MD007592]
- National Natural Science Foundation of China [81172086]
Since intracellular proteins involved in carcinogenesis have been shown to provoke autoantibody responses, autoantibodies can be used as probes in immunoproteomics to isolate, identify, and characterize potential tumor-associated antigens (TAAs). Once a TAA is identified, several approaches will be used to comprehensively characterize and validate the identified TAA/anti-TAA systems that are potential biomarkers in certain types of cancer. Our ultimate goal is to establish rigorous criteria for designation of an autoantibody to a TAA as a cancer biomarker, examine candidate TAAs for sensitivity and specificity of anti-TAA antibody response, and further develop customized TAA arrays that can be used to enhance anti-TAA antibody detection in cancer. This review will mainly focus on the recent advances in our studies using immunoproteomic approach to identify and characterize TAAs as biomarkers in cancer. (C) 2013 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据