期刊
PHYTOTHERAPY RESEARCH
卷 15, 期 8, 页码 676-680出版社
JOHN WILEY & SONS LTD
DOI: 10.1002/ptr.906
关键词
Impatiens balsamina L.; brine shrimp lethality test; Artemia salina; 2-methoxy-1,4-naphthoquinone; antibacterial activity; antifungal activity
By using brine shrimp (Artemia salina) lethality test-guided fractionation, a single bioactive compound (LC50=26 ppm) was isolated from the 95% ethanol extract of the dried aerial parts of Impatiens balsamina L. and subsequently identified as 2-methoxy-1,4-naphthoquinone (MNQ). The structure of MNQ was confirmed by UV, FT-IR, MS, and 1-and 2-D NMR spectroscopy. The antimicrobial activity of MNQ was evaluated using 12 bacterial and eight fungal strains. Five gram-positive and two gram-negative bacteria as well as all eight fungi (including multi-drug resistant strains) tested were highly sensitive to MNQ. A tea prepared according to traditional methods was found to contain sufficient MNQ to account for its antimicrobial properties. Copyright (C) 2001 John Wiley & Sons, Ltd.
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