期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 5, 期 6, 页码 643-649出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/S1367-5931(01)00260-5
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A startling array of added anions have been observed to function as replacement catalytic nucleophiles in mutant glycosidases, including formate, azide, fluoride and other halides. Likewise, the mechanism of acid-base catalysis is somewhat plastic. The carboxylic acids can be substituted by a sulfenic acid or by ascorbate, and the effective acid strength enhanced by the introduction of strong hydrogen bonds, These studies provide an interesting bridge between enzymes and models thereof.
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