期刊
AUTOIMMUNITY REVIEWS
卷 10, 期 12, 页码 744-755出版社
ELSEVIER
DOI: 10.1016/j.autrev.2011.05.004
关键词
FoxP3; Human regulatory T cells; Autoimmune diseases; Systemic Lupus Erythematosus; Rheumatoid Arthritis; Sjogren syndrome
类别
资金
- Institut National et de la Recherche Medicale
- Centre d'Investigation Biologiques Pitie-Salpetriere
- Ministry of Education, Sports, and Culture of Japan
- European Union [LHS-CT-2005-018914]
- APHP
- la Fondation pour la Recherche Medicale
- Japan Society for the Promotion of Science
- Association Lupus France
- la Societe Nationale Francaise de Medecine Interne
- ARTHRITIS Fondation Courtin
Since the characterization of CD4(+)CD25(+) regulatory T (Treg) cells in mice, significant progress has been made in the definitions of the phenotype and the function of human Treg cells in health and in pathological conditions. Recent advances in the field leading to a better molecular definition of Treg subsets in humans and the description of the dynamics of differentiation of Treg cells should bring new insights in the understanding of human chronic systemic autoimmune diseases. How Treg cells are compromised in these diseases is a challenging issue because the elucidation of the mechanisms leading to such anomaly might lead to promising novel therapeutic approaches. (C) 2011 Elsevier B.V. All rights reserved.
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