期刊
AUTOIMMUNITY REVIEWS
卷 9, 期 12, 页码 804-806出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.autrev.2010.06.011
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The B cell-activating factor of the tumor-necrosis factor family (BAFF) plays a dominant role in the B cell homeostasis. By rescuing autoreactive B cells, excessive BAFF favors the development of autoimmune diseases. Given the numbers of variants of this B cell-specific cytokine, caution must be exercised when determining its serum level. Alternate splice isoforms, such as Delta 3 BAFF and Delta 4 BAFF, have been identified. They raise the possibility that their overproduction impact the synthesis of full-length BAFF. (C) 2010 Elsevier B.V. All rights reserved.
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