期刊
AUTOIMMUNITY REVIEWS
卷 9, 期 4, 页码 224-228出版社
ELSEVIER
DOI: 10.1016/j.autrev.2009.08.001
关键词
Sjogren's syndrome; B cell; Rituximab; Epratuzumab; BAFF
类别
Sjogren's syndrome (SS) or autoimmune epithelitis is characterized by focal lymphocytic infiltrates surrounding the tubular epithelium of exocrine glands and by overactivity of the B-cell population. Although T cells were long considered the main effectors in SS, recent findings indicating a key role for B cells have prompted studies of treatments designed to deplete the B-cell population. Among molecules that can be targeted to achieve B-cell depletion, CD20 and CD22 are surface antigens expressed specifically by B lymphocytes; and the cytokine B-cell-activating factor belonging to the TNF family (BAFF) is a TNF receptor ligand involved in B-cell differentiation, survival, and activation. The aim of this review is to discuss the clinical outcomes of SS patients treated with B-cell depletion. (C) 2009 Elsevier B.V. All rights reserved.
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