期刊
JOURNAL OF NEUROSCIENCE RESEARCH
卷 66, 期 5, 页码 839-843出版社
WILEY-BLACKWELL
DOI: 10.1002/jnr.10081
关键词
astrocytes; energy metabolism; lactate; pyruvate; glutamate; glutamine; fructose; mannose; rat optic nerve
资金
- NINDS NIH HHS [T32 NS 07144, NS 15589] Funding Source: Medline
We tested the hypothesis that non-glucose energy sources can support axon function in the rat optic nerve. Axon function was assessed by monitoring the stimulus-evoked compound action potential (CAP). CAP was maintained at full amplitude for 2 hr in 10 mM glucose. 20 mM lactate, 20 mM pyruvate, 10 mM fructose, or 10 mM mannose supported axon function as effectively as did glucose, and 10 mM glutamine provided partial support, but beta -hydroxybutyrate, octanoate, sorbitol, alanine, aspartate, and glutamate failed to support axon function. Our results indicated that a variety of compounds can sustain function in CNS myelinated axons. Axons probably use lactate, pyruvate, and glutamine directly as energy substrates, whereas mannose and fructose could be shuttled through astrocytes to lactate, which is then exported to axons. (C) 2001 Wiley-Liss, Inc.
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