期刊
AUTOIMMUNITY REVIEWS
卷 8, 期 7, 页码 605-610出版社
ELSEVIER
DOI: 10.1016/j.autrev.2009.02.005
关键词
Antiendothelial cell antibodies; Apoptosis; Systemic lupus erythematosus; Systemic vasculitis
类别
Anti-endothelial cell (EC) antibodies (AECA) are a heterogeneous group of antibodies directed against a variety of EC membrane proteins. A pathogenic role for AECA in diseases that involve the vascular system has not been clearly demonstrated. Induction of EC apoptosis appears to be one of the mechanisms by which AECA may exert their effect. AECA from some patients trigger the translocation of anionic phospholipids, most notably phosphatidylserine, from the inner to the outer leaflet of the plasma membrane, and thereafter activation of caspase 3 and cleavage of poly (ADP-ribose) polymerase, hallmarks of apoptosis. Apoptotic cell death generates oxidatively modified moieties, which can induce autoimmune and local inflammatory responses. While a sole AECA target involved in the apoptotic process of ECs has not been identified, some evidence suggests that Heat Shock Proteins may be an outstanding antigen. (C) 2009 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据