期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 194, 期 11, 页码 1639-1647出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.194.11.1639
关键词
cDNA microarrays; gene expression profiling; leukemia; lymphocytic; chronic
资金
- NCI NIH HHS [R01 CA 87956, R01 CA 81554] Funding Source: Medline
The most common human leukemia is B cell chronic lymphocytic leukemia (CLL), a malignancy of mature B cells with a characteristic clinical presentation but a variable clinical course. The rearranged immunoglobulin (Ig) genes of CLL cells may be either germ-line in sequence or somatically mutated. Lack of Ig mutations defined a distinctly worse prognostic group of CLL patients raising the possibility that CLL comprises two distinct diseases. Using genomic-scale gene expression profiling, we show that CLL is characterized by a common gene expression signature, irrespective of Ig mutational status, suggesting that CLL cases share a common mechanism of transformation and/or cell of origin. Nonetheless, the expression of hundreds of other genes correlated with the Ig mutational status, including many genes that are modulated in expression during mitogenic B cell receptor signaling. These genes were used to build a CLL subtype predictor that may help in the clinical classification of patients with this disease.
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