期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 98, 期 25, 页码 14693-14697出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.261432998
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资金
- NIDCD NIH HHS [R01 DC002174, R01 DC04729, R01 DC004729, R01 DC02174, 1 R01 DC04692-01, R01 DC004692] Funding Source: Medline
Olfaction plays a major role in host preference and blood feeding, integral behaviors for disease transmission by the malaria vector mosquito Anopheles gambiae sensu stricto (henceforth A. gambiae). We have identified four genes encoding candidate odorant receptors from A. gambiae that are selectively expressed in olfactory organs, contain approximately seven transmembrane domains, and show significant similarity to several putative odorant receptors in Drosophila melanogaster. Furthermore, one of the putative A. gambiae odorant receptors exhibits female-specific antennal expression and is down-regulated 12 h after blood feeding, a period during which substantial reduction in olfactory responses to human odorants has been observed. Taken together, these data suggest these genes encode a family of odorant receptors in A, gambiae, whose further study may aid in the design of novel antimalarial programs.
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