期刊
NEUROSCIENCE LETTERS
卷 316, 期 1, 页码 5-8出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(01)02341-2
关键词
endoplasmic reticulum stress; caspase-12; manganese; SN4741; Parkinson's disease; dopaminergic cell death
资金
- NIA NIH HHS [AG14093] Funding Source: Medline
- NIEHS NIH HHS [ES10146] Funding Source: Medline
Chronic exposure to manganese causes Parkinson's disease (PD)-like clinical symptoms (Neurotoxicology 5 (1984) 13; Arch. Neurol. 46 (1989) 1104; Neurology 56 (2001) 4). Occupational exposure to manganese is proposed as a risk factor in specific cases of idiopathic PD (Neurology 56 (2001) 8). We have investigated the mechanism of manganese neurotoxicity in nigral dopaminergic (DA) neurons using the DA cell line, SN4741 (J. Neurosci. 19 (1999) 10). Manganese treatment elicited endoplasmic reticulum (ER) stress responses, such as an increased level of the ER chaperone BiP, and simultaneously activated the ER resident caspase-12. Peak activation of other major initiator caspases-like activities, such as caspase-1, -8 and -9, ensued, resulting in activation of caspase-3-like activity during manganese-induced DA cell death. The neurotoxic cell death induced by manganese was significantly reduced in the Bcl-2-overexpressing DA cell lines. Our findings suggest that manganese-induced neurotoxicity is mediated in part by ER stress and considerably ameliorated by Bcl-2 overexpression in DA cells. (C) 2001 Published by Elsevier Science Ireland Ltd.
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