期刊
AUTOIMMUNITY
卷 48, 期 2, 页码 69-72出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/08916934.2014.959165
关键词
Autoimmune; cytokine; inflammation; interleukin-22; rheumatoid arthritis
类别
资金
- Foundation of Anhui Provincial Education Department [KJ2012A156]
- National Science Foundation of China [81273526]
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by synovial inflammation and resultant progressive joint damage. It has become increasingly evident that cytokines play an important role in the pathogenesis of RA. Interleukin-22 (IL-22) is a member of the IL-10 cytokine family. Recent findings suggest that not only the expression of IL-22 is abnormal both in RA patients and in arthritis mice but also the aberrant IL-22 performs significantly in disease onset of RA. In this paper, we focus on the critical role of IL-22 in RA. Hopefully, the information obtained may lead to a better understanding of the pathogenesis and development of novel therapeutic strategies for this systemic autoimmune disease.
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