4.8 Article

Human embryonic genes re-expressed in cancer cells

期刊

ONCOGENE
卷 20, 期 56, 页码 8085-8091

出版社

NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1205088

关键词

human developmental genes; human preimplantation embryo; OCT4; embryo/cancer genes; cancer gene expression

资金

  1. MRC [G9900837, G9826762] Funding Source: UKRI
  2. Medical Research Council [G9900837, G9826762] Funding Source: researchfish
  3. Medical Research Council [G9826762, G9900837] Funding Source: Medline

向作者/读者索取更多资源

Human preimplantation embryonic cells are similar in phenotype to cancer cells. Both types of cell undergo deprogramming to a proliferative stem cell state and become potentially immortal and invasive. To investigate the hypothesis that embryonic genes are re-expressed in cancer cells, we prepare amplified cDNA from human individual preimplantation embryos and isolate embryo-specific sequences. We show that three novel embryonic genes, and also the known gene, OCT4, are expressed in human tumours but not expressed in normal somatic tissues. Genes specific to this unique phase of the human life cycle and not expressed in somatic cells may have greater potential for targeting in cancer treatment.

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