期刊
NEURON
卷 32, 期 5, 页码 947-955出版社
CELL PRESS
DOI: 10.1016/S0896-6273(01)00519-0
关键词
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资金
- NIA NIH HHS [AG13483, AG15793] Funding Source: Medline
- NIGMS NIH HHS [T32-GM07517] Funding Source: Medline
- NINDS NIH HHS [NS01762] Funding Source: Medline
Anatomic structures have been linked to the mnemonic component of working memory, but the neural network underlying associated decision processes remains elusive. Here we present an event-related functional magnetic resonance imaging study that measured activity during the decision period of a delayed face recognition task. A double dissociation of activity between anterior cingulate cortex (ACC), and a network including left fusiform face area (FFA) and left dorsolateral prefrontal cortex (DLPFC), reflected whether a probe face matched the remembered face at the time of decision. Greater activity in the left FFA and left DLPFC correlated with probe faces that matched the remembered face; in contrast, activity in ACC was greater when the probe face did not match the remembered face. These results support a model where frontal regions act in concert with stimulus-specific temporal structures to make recognition decisions about visual stimuli.
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