期刊
AUTOIMMUNITY
卷 43, 期 3, 页码 236-238出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/08916930903510948
关键词
Inflammation; SLE; cytokines; blood-borne phagocytes; MSU
类别
资金
- University Clinic of Erlangen [06.11.06.1]
- DFG [HE 4490/3-1]
- SFB [643, GK643]
- K. und R. Wucherpfennigstiftung
Accumulation in tissues of post-apoptotic cells is a feature frequently observed in patients with systemic lupus erythematosus and in murine models of systemic autoimmune diseases. One of the endogenous danger molecules released by secondarily necrotic cells is monosodium urate (MSU), which is already established to be the causative agent of gout. Here, we show that MSU is taken up by eosinophils, neutrophils and monocytes in a process involving (a) heat-labile serum factor(s) and divalent cations. The uptake induces the release of the pro-inflammatory cytokines IL-1 beta/IL-18/TNF alpha and IL-6/IL-8 by monocytes and PMN, respectively.
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