期刊
AUTOIMMUNITY
卷 42, 期 3, 页码 198-202出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/08916930802668594
关键词
ANCA; vasculitis; avidity; myeloperoxidase; antigen stimulation
类别
资金
- Chinese 985 project [985-2-104-113]
Antineutrophil cytoplasmic antibodies (ANCA) are important serologic markers for ANCA-associated vasculitis (AAV). Our previous studies in propylthiouracil (PTU)-induced AAV demonstrated that withdrawal of PTU resulted in clinical remission and significant decrease of avidity of PTU-induced myeloperoxidase (MPO)-ANCA. This study investigated the changes in avidity and titer of MPO-ANCA in sequential sera from some patients with primary AAV with different disease activities. Sequential sera samples of seven patients with MPO-ANCA-positive vasculitis at their initial onset, remission and relapse were collected. The avidity of MPO-ANCA was assessed by antigen-inhibition enzyme-linked immunosorbent assay (ELISA). The titer of MPO-ANCA was determined by a two-fold dilution of sera in MPO specific ELISA. The titer of MPO-ANCA was not significantly different between initial onset and remission. The avidity constant (aK) of MPO-ANCA in active phase is not significantly different from that in remission (724.9828.4l/mol vs. 353.4551.7l/mol, p=0.303). No significant correlation could be found between aK and the level of Birmingham Vasculitis Activity Score, times of relapse, the number of organ involvement, serum creatinine, or CRP. Avidity and titer of MPO-ANCA did not decreased significantly during remission in AAV, indicating the chronic repeated antigen stimulation was not removed, which might be the reason for recurrent relapses.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据