期刊
JOURNAL OF IMMUNOLOGY
卷 167, 期 12, 页码 6711-6715出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.167.12.6711
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资金
- NIAID NIH HHS [AI49466, AI41643, AI44644] Funding Source: Medline
Despite declining thymic output with age, the peripheral naive T cell pool of an adult animal remains remarkably stable. Therefore, a central question in immunology is how the naive T cell pool is maintained. Here we show that the maintenance of the naive CD4, but not CD8, T cell population in the thymectomized adult mouse is dependent on the presence of secondary lymphoid tissues. This finding is explained by the inability of naive CD4 T cells to sustain normal levels of the survival molecule Bcl-2 or to undergo homeostatic proliferation in the absence of secondary lymphoid organs. Thus, naive CD4 T cells must traffic through secondary lymphoid organs to maintain a stable CD4 pool while naive CD8 T cells encounter their survival and proliferation signals outside the organized structures of secondary lymphoid tissues.
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