期刊
AUTISM RESEARCH
卷 5, 期 5, 页码 289-313出版社
WILEY
DOI: 10.1002/aur.1243
关键词
diffusion tensor imaging; neuroimaging; autism; white matter
资金
- National Institute of Child Health and Human Development (NICHD) [T32 HD07 489, P30 HD003352]
- National Institute of Mental Health (NIMH) [P50 MH84051, RO1 MH080826]
- Morgridge Institutes for Research (MIR-University of Wisconsin)
White matter tracts of the brain allow neurons and neuronal networks to communicate and function with high efficiency. The aim of this review is to briefly introduce diffusion tensor imaging methods that examine white matter tracts and then to give an overview of the studies that have investigated white matter integrity in the brains of individuals with autism spectrum disorder (ASD). From the 48 studies we reviewed, persons with ASD tended to have decreased fractional anisotropy and increased mean diffusivity in white matter tracts spanning many regions of the brain but most consistently in regions such as the corpus callosum, cingulum, and aspects of the temporal lobe. This decrease in fractional anisotropy was often accompanied by increased radial diffusivity. Additionally, the review suggests possible atypical lateralization in some white matter tracts of the brain and a possible atypical developmental trajectory of white matter microstructure in persons with ASD. Clinical implications and future research directions are discussed. Autism Res 2012, 5: 289313. (C) 2012 International Society for Autism Research, Wiley Periodicals, Inc.
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