Direct asymmetric synthesis of oxazolines from olefins using a chiral nitridomanganese complex: a novel three-component coupling leading to chiral oxazolines

A new synthetic method for chiral oxazolines has been developed by NI unit transfer to olefins using a chiral nitridomanganese complex. When trans-disubstituted styrenes were treated with chiral complex I in the presence of an acid chloride. oxazolines were obtained with high enantioselectivities (up to 92% ee). Furthermore. the produced oxazolines could be easily converted into beta -amino alcohols, which are ephedrine derivatives, (C) 2001 Elsevier Science Ltd. All rights reserved.