期刊
AUTISM RESEARCH
卷 3, 期 5, 页码 203-213出版社
WILEY
DOI: 10.1002/aur.146
关键词
autism; Asperger syndrome; white matter; DTI; connectivity
资金
- MRC UK A.I.M.S. network
- Maudsley NHS Trust
- South London
- MRC [G0400061] Funding Source: UKRI
- Medical Research Council [G0400061] Funding Source: researchfish
- National Institute for Health Research [RP-PG-0606-1045] Funding Source: researchfish
Background: Autistic Spectrum Disorder (ASD), including Asperger syndrome and autism, is a highly genetic neurodevelopmental disorder. There is a consensus that ASD has a biological basis, and it has been proposed that it is a connectivity disorder. Diffusion Tensor Magnetic Resonance Imaging (DT-MRI) allows measurement of the microstructural integrity of white matter (a proxy measure of connectivity). However, nobody has investigated the microstructural integrity of whole brain white matter in people with Asperger syndrome. Methods: We measured the fractional anisotropy (FA), mean diffusivity (MD) and radial diffusivity (RD) of white matter, using DT-MRI, in 13 adults with Asperger syndrome and 13 controls. The groups did not differ significantly in overall intelligence and age. FA, MD and RD were assessed using whole brain voxel-based techniques. Results: Adults with Asperger syndrome had a significantly lower FA than controls in 13 clusters. These were largely bilateral and included white matter in the internal capsule, frontal, temporal, parietal and occipital lobes, cingulum and corpus callosum. Conclusions: Adults with Asperger syndrome have widespread significant differences from controls in white matter microstructural integrity.
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