期刊
NEUROREPORT
卷 12, 期 18, 页码 3897-3900出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200112210-00008
关键词
development; glia; ventrobasal thalamus
During development, astrocytes in the ventrobasal thalamus display spontaneous intracellular calcium [Ca2+](i) oscillations, that can lead to the excitation of adjacent thalamocortical neurons via an NMDA receptor- mediated mechanism. In this study, we show that while astrocytes usually exhibit oscillations of irregular amplitude and frequency, a subset of spontaneously active thalamic astrocytes exhibits rhythmic, i.e. pacemaker, [Ca2+](i), oscillations with an average frequency of 0.019 Hz. This frequency of the pacemaker oscillations is close to the modal frequency of the irregularly oscillating astrocytes, suggesting that there is a preferred frequency for astrocytic [Ca2+](i), oscillations. If pacemaker [Ca2+](i) oscillations underlie excitatory signaling to neurons, the result would be rhythmic activation of thalamocortical neurons and astrocyte-driven synchronized oscillations within neurons of the thalamocortical loop. NeuroReport 12:3897-3900 (C) 2001 Lippincott Williams & Wilkins.
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