期刊
NEUROREPORT
卷 12, 期 18, 页码 3953-3957出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200112210-00020
关键词
anxiety; fMRI; neuroanatomy; neuroimaging; panic
资金
- NIMH NIH HHS [P20-MHDA52176] Funding Source: Medline
While undergoing fMRI, six patients with DSM IV diagnosis of panic disorder and six normal controls performed directed imagery of neutral, moderate and high anxiety situations based on an individually determined behavioral hierarchy. Brain activity was compared during high vs neutral anxiety blocks for each group of subjects using SPM99b. Panic patients showed increased activity in inferior frontal cortex, hippocampus and throughout the cingulate both anterior and posterior, extending into the orbitofrontal cortex and encompassing both hemispheres. These areas may constitute the important circuit in the psychopathology of panic, disorder. We propose that this pattern of activity may enhance the encoding and retrieval of strong emotional events, facilitating the recapitulation of traumatic experiences and leading to panic disorder in vulnerable individuals. NeuroReport 12:3953-3957 (C) 2001 Lippincott Williams & Wilkins.
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