期刊
TETRAHEDRON
卷 57, 期 52, 页码 10309-10317出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4020(01)01056-0
关键词
ynamines; electrophilic addition; trimethylsilyl cyanide; cyanogens bromide; alpha-cyanoenamines; cross-coupling
The reactions of trimethylsilyl cyanide and tributyltin cyanide with ynamines proceeds as a regioselective syn-addition and provide previously unknown beta -elementosubstituted alpha -cyanoenamines as pure E-isomers. The reaction of cyanogen bromide with ynamines as well the hydrocyanation of phosphorus substituted N,N-diethylaminoacetylenes by acetone cyanohydrin also proceeds as regioselective syn-addition, though the initially formed Z-isomers undergo an easy transformation into E-isomers. Cross-coupling reaction of beta -bromo-otcyanocnamine with arylboronic acids were shown to be an easy and convenient approach to alpha -dialkylaminosubstituted cynnamonitriles. (C) 2001 Elsevier Science Ltd. All fights reserved.
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