Highly efficient and mild synthesis of variously 5-substituted-4-carbaldehyde-1,2,3-triazole derivatives

Synthesis of variously 5-substittited-4-carbaldehyde-1,2,3-triazole derivatives 2 was accomplished by reacting sodium azide with alpha,beta -acetylenic aldehydes I in DMSO at room temperature. Therefore. the reaction remains basic avoiding the generation of the hazardous explosive HN3, resulting in a safe process. This mild and general reaction was instantaneous and was essentially quantitative. (C) 2001 Elsevier Science Ltd. All rights reserved.