The complexes [Cu(CTZ)(4)]Cl(2)(.)2H(2)O (1), [Cu(CTZ)Cl-2](2) (2), [Cu(KTZ)(3)Cl-2] (3), and [Cu(KTZ)Cl-2](2)(.)2H(2)O (4) were prepared by reaction Of CuCl2 with CTZ and KTZ (where CTZ = 1-[[(2-chlorophenyl)diphenyl]methyl]-1H-imidazole and KTZ = cis-1-acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine), respectively, in acetonitrile at different ligand to metal molar ratios. Gold complexes [Au(PPh3)(CTZ)]PF6 (5) and [Au(PPh3)(KTZ)](PF6H2O)-H-. (6) were synthesized by reaction of AuClPPh3, with KPF6 and CTZ or KTZ in acetonitrile. All the new compounds were characterized by NMR spectroscopy and microanalytical methods, and for the paramagnetic species EPR spectroscopy and DC magnetic susceptibility measurements were also employed. The solid-state structure of 1 has been determined by X-ray crystallography. 1 crystallizes in the triclinic space group P1, with a = 12.773(2) Angstrom, b = 15.326(4) Angstrom, c 11.641(2) Angstrom, V = 1957.4(7) Angstrom (3)' Z = 1, and D-calcd = 1.284 g/cm(3). The structure refinement converged at R1 = 0.0731 and wR2 = 0.1962. Complex 1 displayed a square-planar structure typical for tetrakis(imidazole)copper(fl) complexes. The new compounds were tested for in vitro activity against cultures of epimastigotes of Trypanosoma crud, the causative agent of Chagas disease. At concentrations equivalent to 10(-6) M of total CTZ or KTZ (in DMSO) all the complexes exhibited significantly higher growth inhibitory activity than their respective parental compounds.
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