Covalent immobilization of DNA on diamond and its verification by diffuse reflectance infrared spectroscopy

immobilization of DNA on diamond surfaces and detection of its covalently bonded nature were explored by direct spectroscopic analysis. Fine diamond powder was successfully modified by oxidation, followed by esterification. DNA covalently immobilized onto diamond through ester linkage was detected by diffuse reflectance infrared spectroscopic analysis. (C) 2002 Elsevier Science B.V. All rights reserved.