期刊
JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS
卷 50, 期 2-3, 页码 111-121出版社
ELSEVIER
DOI: 10.1016/S0165-022X(01)00177-4
关键词
FTIR microscopy; cancer; diagnosis; malignant cells; retroviruses; IR spectroscopy; NIH/3T3 cells
Fourier transform infrared (FTIR) spectroscopy is a unique technique for the laboratory diagnosis of cellular variations based on the characteristic molecular vibrational spectra of the cells. Microscopic FTIR was used to investigate spectral differences between normal and malignant fibroblasts transformed by retrovirus infection. A detailed analysis showed significant differences between cancerous and normal cells. The contents of vital cellular metabolites were significantly lower in the transformed cells than in the normal cells. In an attempt to identify the cellular components responsible for the observed spectral differences between normal and cancerous cells, we found significant differences between DNA of normal and cancerous cells. (C) 2002 Published by Elsevier Science B.V.
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