期刊
NEUROLOGY
卷 58, 期 1, 页码 127-129出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.58.1.127
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The concentration of the cyclooxygenase product prostaglandin E, was sixfold higher in CSF samples from 18 cases of variant Creutzfeldt-Jakob disease (CJD) than in a group of eight subjects with other noninflammatory neurologic diseases, and comparable to those found in a group of six patients affected by diseases with a known inflammatory component. This finding suggests that cyclooxygenase activity may have a role in variant CJD pathogenesis, as previously reported in sporadic CJD.
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