期刊
VACCINE
卷 20, 期 7-8, 页码 1089-1098出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0264-410X(01)00444-3
关键词
vaccine delivery system; single dose vaccine; humoral immunity
Two continuous delivery injectable silicone implants were tested to determine if they were capable of delivering vaccines in a single shot. The Type A implant delivers antigen in vitro over a 1-month-period and the Type B over several months. Vaccination studies in sheep were designed to compare the responses induced by the Type A and B implants, Alzet(TM) mini-osmotic pumps and conventional antigen delivery. A model antigen, avidin, was used along with IL-Ibeta or alum as adjuvants. Sheep were immunised with various formulations and the titre and isotype of the antigen specific antibodies monitored. The Type B implant induced antibody (Ab) titres of greater magnitude and duration than soluble vaccines or the Type A implant with adjuvant, but only if IL-1beta was included in the formulation. Both implants induced antibodies of IgG1 and IgG2 isotype. A memory response to soluble antigen challenge was induced by the Type B+IL-1beta implant, which was predominantly of an IgG1 isotype. (C) 2002 Elsevier Science Ltd. All rights reserved.
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