期刊
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
卷 27, 期 3-4, 页码 531-540出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0731-7085(01)00579-9
关键词
chiral recognition; cyclodextrins; ephedrine derivatives; capillary electrophoresis; nuclear magnetic resonance
The resolution of chiral phenethylamine analogue compounds were studied in presence of single-isomer neutral and negatively charged cyclodextrins (CDs) by means of capillary electrophoresis (CE) and NMR spectroscopy. Whereas the native beta-CD and heptakis(2-N,N-dimethylcarbamoyl) beta-cyclodextrin were not able to separate the racemates of four ephedrine derivatives studied, heptakis(2,3-O-diacetyl) beta-cyclodextrin and especially heptakis(2,3-O-diacetyl-6-sulfo) beta-cyclodextrin could resolve all four pairs of enantiomers in one run. UV and NMR spectroscopic measurements revealed various kinds of complexes of phenethylamines with the CDs. Either defined inclusion complexes or manifold complexes which are mostly characterized by an attachment of the analyte to the outside of the CD cavity were found. No correlation between the kind of complexation and the resolution observed by means of CE could be found. (C) 2002 Elsevier Science B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据