期刊
JOURNAL OF CONTROLLED RELEASE
卷 78, 期 1-3, 页码 259-266出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0168-3659(01)00494-1
关键词
cationic liposomes; naked DNA; gene delivery
资金
- NCI NIH HHS [CA 74918] Funding Source: Medline
- NIAID NIH HHS [AI 48851] Funding Source: Medline
- NIAMS NIH HHS [AR 45925] Funding Source: Medline
- NIDDK NIH HHS [DK 44935, DK 54225] Funding Source: Medline
dOne of the major challenges for gene therapy is systemic delivery of a nucleic acid directly into an affected tissue, This requires developing a vehicle which is able to protect the nucleic acid from degradation, while delivering the gene of interest to the specific tissue and specific subcellular compartment. In this review, we summarize some of the recent advances in new non-viral delivery systems for systemic administration. Two types of gene delivery systems are described: (i) LPD1 (cationic liposome-entrapped, polycation-condensed DNA, type 1), and (ii) retention-time mediated naked DNA delivery. Hypothesized mechanisms for these systemic gene transfers are also discussed. (C) 2002 Elsevier Science B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据