期刊
NEUROREPORT
卷 13, 期 1, 页码 53-56出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200201210-00015
关键词
brain; first trimester; human; IFN-gamma; T brucei
We addressed the host-parasite interplay and the immunopathogenetic events occurring in the central nervous system (CNS) during human African trypanosomiasis. Human first trimester forebrain cells were stimulated with a trypanosome lymphocyte-triggering factor (TLTF) and studied for their immune response as exemplified by cell proliferation and IFN-gamma production. TLTF induced proliferation of human first trimester forebrain cells and IFN-gamma production at the mRNA and protein levels. Astrocytes are the major producers of IFN-gamma in response to TLTF. These data illustrated for the first time a direct effect of a parasite factor on human brain cells. Targeting TLTF during the course of the disease may be considered in preventing the deadly neurological complications of human African trypanosomiasis. NeuroReport 13:53-56 (C) 2002 Lippincott Williams Wilkins.
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