期刊
BEHAVIOURAL BRAIN RESEARCH
卷 128, 期 2, 页码 189-203出版社
ELSEVIER
DOI: 10.1016/S0166-4328(01)00321-7
关键词
incentive sensitization; amphetamine; conditioned place-preference; sexual pursuit; food-seeking; appetitive; consummatory
Appetitive behavior for drug and sexual reward is enhanced in animals with a history of amphetamine-experience. The present experiment investigated whether prior exposure to a sensitizing regimen of amphetamine treatment would 'globally' enhance future appetitive behaviors of adult male Sprague-Dawley rats, and whether the drug preexposure-environment or intermittency of administration would affect this development. Reward appetite was compared in drug-experienced versus drug-naive rats using amphetamine place-p reference conditioning (CPP) and a natural-incentive sensitization task, which measured appetitive approach for food and sexual reward. Experiment 1 found that 10 daily exposures to 1 mg/kg amphetamine did not alter future psychostimulant CPP, regardless of abstinence schedule. Although daily exposure to a higher amphetamine dose also did not alter appetitive behavior when measured after 2-weeks drug abstinence in Experiment II, alternate-day amphetamine experience (5.0 mg/kg, twice-a-day) in an initially unfamiliar environment persistently enhanced future amphetamine CPP and appetitive behavior for natural reward. Identical treatment administered in the homecage did not. Furthermore, sensitized reward-seeking behaviors were not globally evident. Animals that showed sensitized amphetamine CPP did not show sensitized food-seeking behavior and vice versa. Thus, the environment surrounding chronic psychostimulant drug experience can greatly affect subsequent reward appetite, but the sensitized expression may be individually determined. (C) 2002 Elsevier Science B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据