期刊
NEUROLOGY
卷 58, 期 2, 页码 305-307出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.58.2.305
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To examine possible metabolic frontal lobe alterations in IV heroin-dependent patients with different histories of concomitant substance use, N-acetylaspartate (NAA), a putative marker of neuronal viability, was measured by H-1-MRS. Compared with controls, NAA levels in patients were reduced by 7% in gray matter (p = 0.015) but not in white matter. To what extent comorbid conditions or substance use, including alcohol, contributed to these frontocortical metabolic changes remains to be elucidated.
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